Wolfe Laboratories, Inc. Postdoctoral Position

POSTDOCTORAL SCIENTIST

JOB SUMMARY: We require a highly motivated Postdoctoral Scientist to work on
protein stability & aggregation as it relates to therapeutic protein development. The
current postdoctoral project is designed to understand the fundamental mechanism/s of
protein instability, sub-visible particulate formation and aggregation using variety of
chromatographic, biophysical and biochemical tools.

DUTIES AND RESPONSIBILITIES:
SCIENTIFIC RESPONSIBILITIES:
• Evaluate physical and biophysical properties of peptides and proteins relevant to
drug development and subsequently communicate the interpretation and
implication of results to clients.
• Develop analytical methods and characterize product variants
• Execute and oversee specialized analytical testing and generation of technical
documents
• Maintain a strong awareness of current scientific literature, particularly in the area
of protein characterization, and actively apply new concepts as appropriate.
• Develop and evaluate new cutting-edge technologies for protein product
understanding, especially product heterogeneity and impact on safety and
efficacy.
• Design experiments to develop pre-clinical and clinical formulations of drug
candidates to support drug discovery and development.
• Design experiments to determine the stability in prototype clinical formulations,
to detect and identify the decomposition products, and to achieve formulations
with acceptable shelf-life.
• Perform laboratory experiments related to the above.
• Create presentations for outside scientific meetings and conferences to showcase
Wolfe Laboratories’ scientific leadership in the field of protein analysis and
characterization.

CLIENT INTERACTION RESPONSIBILITIES:
• Interface with clients to develop an in-depth understanding of client objectives
and define solutions to meet their program requirements
• Develop compelling approaches and solutions to address client needs
• Write persuasive proposals for the projects
• Regularly interact with clients to keep them abreast of project progress
• Write and review interim and final reports.

REQUIRED BACKGROUND AND EXPERIENCE:
• Ph.D. in Biochemistry, Biophysics, Chemistry or closely related disciplines
• In depth experience in the area of protein biophysical chemistry of proteins
involving structure-folding-stability relationships. This includes purification,
stability, kinetics and thermodynamics of folding of monomeric proteins,
particularly as they relate to the pre-formulation and formulation development of
new drugs
• Hands-on experience with chromatographic method development as well as
techniques used for biophysical characterization of biopharmaceutical products
such as calorimetry, spectroscopy, higher order structure analysis, protein mass
spectroscopy, CE, HPLC, ELISA, and carbohydrate analysis.
• A demonstrated drive to apply technical knowledge to developing drug
formulations
• Established track record of significant contributions as an individual technical
expert
• Outstanding written and oral communication skills as well as polished and
persuasive client presentation skills

ADDITIONAL DESIRABLE BACKGROUND:
• Post doctoral experience in analytical biochemistry or closely related discipline.
• Good understanding of excipient and ligand interaction with proteins
• Evaluation of thermodynamic and kinetic models

Interested candidates are requested to email a copy of their resume with a cover letter
including salary history to: steve.pangione@wolfelabs.com

Wolfe Laboratories, Inc. (WLI), located in Watertown, MA, is a premier contract research
organization that provides integrated early drug development solutions to the biopharmaceutical
industry. Wolfe Laboratories is an essential element of the drug development ecosystem,
recognized by global and virtual biopharmaceutical companies as a science-driven organization
whose mission is to provide outstanding discovery and development services tailored to its
clients’ needs for rational formulation development. Wolfe Laboratories integrates the critical
path components of early development to ensure that programs advance while meeting rigorous
scientific demands with flexibility to address dynamic challenges and aggressive timelines.
Wolfe Laboratories’ vision is to improve human health, and we continue to strive towards that
goal by embracing our core values of integrity, excellence and teamwork. The company has a
high percentage of repeat clients, which is a testament to its long-term commitment of continual
investment in its capabilities to meet biopharma’s growing demand for high quality, integrated
early development services.

We have a steady 12-year track record of growth, success and profitability.

For more information visit us at: http://www.wolfelabs.com.
Wolfe Laboratories, Inc is an Equal Employment Opportunity employer.